The Colts' loss clinched playoff spots for the Bills and Chargers. The 49ers had already clinched their spot in the NFC, and ...

The San Francisco 49ers offense is cruising and they were dominant in a win over the Indianapolis Colts. Here are the ...

The Indianapolis Colts lose to the San Francisco 49ers in NFL Week 16 action on 'Monday Night Football': Score updates, ...

Philip Rivers starts again when he takes on the ferocious 49ers on "Monday Night Football." Here's score, highlights, stats and more for Colts-49ers.

In order for the Colts to come away with a much-needed win, here are three keys to accomplishing that. The Colts' downfield ...

The San Francisco 49ers are headed to Indianapolis for a Week 16 matchup against the Colts, and they now officially know who they'll be facing under center. While it was expected that quarterback ...

Indianapolis Colts vs San Francisco 49ers picks, predictions, win probabilities for NFL Week 16 Monday Night Football game on ...

Head Coach Kyle Shanahan and the Niners now control their fate in their pursuit of the NFC West crown and the top overall seed in the NFC. The scary part for the rest of the NFC is San Francisco is ...

The ESPN broadcast announced that Kittle is questionable to return due to an ankle injury. The tight end exited the game with seven catches for 115 yards and a touchdown on eight targets.

The Week 16 edition of "Monday Night Football" between the Indianapolis Colts (8-7) and the San Francisco 49ers (11-4) will ...