Bacterial gene regulation is a finely tuned process essential for cellular adaptation and survival. Central to this regulation are nucleoid-associated proteins (NAPs), which not only compact the ...

Engineered oncolytic bacteria have emerged as a promising therapeutic platform for precision cancer treatment, offering tumor-specific colonization, immune activation, and controllable therapeutic ...

Researchers turned programmable proteins into a novel genetic tool, potentially enabling tighter control of gene expression. LacI is a tetrameric protein, using two dimers to bind two specific, ...

DNA methylation in bacteria, primarily involving the addition of methyl groups to adenine or cytosine residues, constitutes a pivotal epigenetic mechanism that modulates gene expression without ...

In the microscopic world of bacteria, gene transfer is a powerful mechanism that can alter cellular function, drive antibiotic resistance and even shape entire ecosystems. Now an interdisciplinary ...

siMecA-AGO2 complex inhibits the translation of the mecA gene which encodes the penicillin-binding protein 2a (PBP2a), a protein at the heart of the drug-resistance phenotype in MRSA. By reducing ...

A newly discovered promoter element "start" points to a shared regulatory syntax for controlling transcription initiation in bacteria, archaea, and eukaryotes.

Scientists studying thousands of rats discovered that gut bacteria are shaped by both personal genetics and the genetics of ...