Involvement of M2 macrophages polarization in PM2.5-induced COPD …
Sep 15, 2024 · Single cell analysis of lung tissues from COPD patients and mice further revealed that M2 macrophages were the dominant macrophage subpopulation in COPD, with MMP12 being …
Airway MMP-12 and DNA methylation in COPD: an integrative approach
As genetic determinants are important for COPD pathogenesis, we tested whether the identified epigenetic variation related to both MMP-12 and COPD was colocalized with genetic variants linked …
Targeting MMP12 in COPD: Novel Insights Into Local Sirna Delivery …
May 1, 2025 · Conclusions: This study presents the first application of local siRNA delivery targeting MMP12 in lung macrophages for COPD treatment. Our approach offers a precise therapeutic …
May 21, 2024 · This study aimed to investigate the interaction between the polymorphisms of MMP1, MMP2, MMP9 and MMP12 genes and its combined effect with smoking on the risk of devel-oping …
Airway MMP-12 and DNA methylation in COPD: an integrative approach
Jan 10, 2025 · To evaluate the effect of COPD on protein–DNA methylation-relationships, an interaction pEWAS was implemented. All pQTMs were annotated to genes, and interaction pQTMs were tested …
significant association of the MMP-12 rs652438 and MMP-3 rs35068180 polymorphisms with COPD. Conclusions: The findings of this meta-analysis suggest that there is a risk of COPD ass Key words: …
Association of MMP - 12 polymorphisms with severe and very severe COPD …
In COPD patients a range of studies implicate MMP s in the pathogenesis of the disease [7 - 12]. A number of studies have reported associations of genetic variants in MMPs-1, 9 and 12 with COPD or …
An overview of matrix metalloproteinase-12 in multiple disease ...
Feb 5, 2025 · Here, this comprehensive review discusses the pathophysiological contributions of MMP-12 in various diseases including COPD, emphysema, inflammatory disorders, and different types of …
MMP12, lung function, and COPD in high-risk populations
Dec 31, 2009 · The minor allele of a SNP in MMP12 (rs2276109) is associated with a positive effect on lung function in children with asthma and in adults who smoke. This allele is also associated with a …
MMP12, lung function, and COPD in high-risk populations
Dec 1, 2009 · Abstract Genetic variants influencing lung function in children and adults may ultimately lead to the development of chronic obstructive pulmonary disease (COPD), particularly in high-risk …